Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
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چکیده
منابع مشابه
Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
Cell cycle arrest is not yet senescence. When the cell cycle is arrested, an inappropriate growth-promotion converts an arrest into senescence (geroconversion). By inhibiting the growth-promoting mTOR pathway, rapamycin decelerates geroconversion of the arrested cells. And as a striking example, while causing arrest, p53 may decelerate or suppress geroconversion (in some conditions). Here I dis...
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DNA damaging agents and radiation, cytotoxins and anti-cancer drugs, telomere erosion and cytokines, culture shock and mitogenic stimuli, oncogenes and tumor suppressors can induce both cell cycle arrest and cellular senescence. Due to this semi-coincidence, senescence is confused with cell cycle arrest, or even more misleadingly, with growth inhibition. With such misconceptions, cellular senes...
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p21, a regulatory molecule upstream of the G1/0 checkpoint, is increased in -cells in response to mitogenic stimulation. Whereas p21 can variably stimulate or inhibit cell cycle progression, in vitro studies suggest that p21 acts as an inhibitor in the pancreatic -cell. To determine the functional role of p21 in vivo, we studied p21-null mice. Surprisingly, islet mass, -cell replication rates, ...
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Berberine (BRB), a natural alkaloid, has a long history of medicinal use in both Ayurvedic and old Chinese medicine. Recently, available as a dietary supplement, Berberine is reported to have application in treatment of variety diseases. Previously we observed that BRB inhibited mTOR/S6 signaling concurrently with reduction of the level of endogenous oxidants and constitutive DNA damage respons...
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Introduction Cells transverse the cell-cycle in several well-controlled phases (1). In the G1 phase, cells commit to enter the cell-cycle and prepare to duplicate their DNA in S phase. After S phase, cells enter the G2 phase, where repair might occur along with preparation for mitosis in M phase. In the M phase, chromatids and daughter cells separate. After M phase, the cells can enter G1 or G0...
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ژورنال
عنوان ژورنال: Aging
سال: 2012
ISSN: 1945-4589
DOI: 10.18632/aging.100443